BiopestPeptidV1, Main, Exploration, bibRecord, 000A69

2-Bromo-4'-methoxychalcone and 2-Iodo-4'-methoxychalcone Prevent Progression of Hyperglycemia and Obesity via 5'-Adenosine-Monophosphate-Activated Protein Kinase in Diet-Induced Obese Mice.

Identifieur interne : 000A69 ( Main/Exploration ); précédent : 000A68; suivant : 000A70

2-Bromo-4'-methoxychalcone and 2-Iodo-4'-methoxychalcone Prevent Progression of Hyperglycemia and Obesity via 5'-Adenosine-Monophosphate-Activated Protein Kinase in Diet-Induced Obese Mice.

Auteurs : Chi-Ting Hsieh [Taïwan] ; Fang-Rong Chang [Taïwan] ; Yi-Hong Tsai [Taïwan] ; Yang-Chang Wu [Taïwan] ; Tusty-Jiuan Hsieh [Taïwan]

Source :

International journal of molecular sciences [ 1422-0067 ] ; 2018.

RBID : pubmed:30223438

Descripteurs français

KwdFr :
- AMP-Activated Protein Kinases (métabolisme), Activation enzymatique (MeSH), Adipocytes (effets des médicaments et des substances chimiques), Adipocytes (métabolisme), Alimentation riche en graisse (effets indésirables), Animaux (MeSH), Chalcones (composition chimique), Chalcones (pharmacologie), Fibres musculaires squelettiques (effets des médicaments et des substances chimiques), Fibres musculaires squelettiques (métabolisme), Glucose (métabolisme), Hyperglycémie (métabolisme), Hyperglycémie (prévention et contrôle), Hyperglycémie (sang), Hypoglycémiants (composition chimique), Hypoglycémiants (pharmacologie), Lignée cellulaire (MeSH), Modèles animaux de maladie humaine (MeSH), Métabolisme lipidique (effets des médicaments et des substances chimiques), Obésité (métabolisme), Obésité (prévention et contrôle), Obésité (sang), Obésité (étiologie), Protéines liant les séquences stimulatrices de type CCAAT (métabolisme), Récepteur PPAR gamma (métabolisme), Souris (MeSH), Évolution de la maladie (MeSH).
MESH :
- composition chimique : Chalcones, Hypoglycémiants.
- effets des médicaments et des substances chimiques : Adipocytes, Fibres musculaires squelettiques, Métabolisme lipidique.
- effets indésirables : Alimentation riche en graisse.
- métabolisme : AMP-Activated Protein Kinases, Adipocytes, Fibres musculaires squelettiques, Glucose, Hyperglycémie, Obésité, Protéines liant les séquences stimulatrices de type CCAAT, Récepteur PPAR gamma.
- pharmacologie : Chalcones, Hypoglycémiants.
- prévention et contrôle : Hyperglycémie, Obésité.
- sang : Hyperglycémie, Obésité.
- étiologie : Obésité.
- Activation enzymatique, Animaux, Lignée cellulaire, Modèles animaux de maladie humaine, Souris, Évolution de la maladie.

English descriptors

KwdEn :
- AMP-Activated Protein Kinases (metabolism), Adipocytes (drug effects), Adipocytes (metabolism), Animals (MeSH), CCAAT-Enhancer-Binding Proteins (metabolism), Cell Line (MeSH), Chalcones (chemistry), Chalcones (pharmacology), Diet, High-Fat (adverse effects), Disease Models, Animal (MeSH), Disease Progression (MeSH), Enzyme Activation (MeSH), Glucose (metabolism), Hyperglycemia (blood), Hyperglycemia (metabolism), Hyperglycemia (prevention & control), Hypoglycemic Agents (chemistry), Hypoglycemic Agents (pharmacology), Lipid Metabolism (drug effects), Mice (MeSH), Muscle Fibers, Skeletal (drug effects), Muscle Fibers, Skeletal (metabolism), Obesity (blood), Obesity (etiology), Obesity (metabolism), Obesity (prevention & control), PPAR gamma (metabolism).
MESH :
- chemical , chemistry : Chalcones, Hypoglycemic Agents.
- chemical , metabolism : AMP-Activated Protein Kinases, CCAAT-Enhancer-Binding Proteins, Glucose, PPAR gamma.
- adverse effects : Diet, High-Fat.
- blood : Hyperglycemia, Obesity.
- drug effects : Adipocytes, Lipid Metabolism, Muscle Fibers, Skeletal.
- etiology : Obesity.
- metabolism : Adipocytes, Hyperglycemia, Muscle Fibers, Skeletal, Obesity.
- chemical , pharmacology : Chalcones, Hypoglycemic Agents.
- prevention & control : Hyperglycemia, Obesity.
- Animals, Cell Line, Disease Models, Animal, Disease Progression, Enzyme Activation, Mice.

Abstract

Obesity and diabetes are global health-threatening issues. Interestingly, the mechanism of these pathologies is quite different among individuals. The discovery and development of new categories of medicines from diverse sources are urgently needed for preventing and treating diabetes and other metabolic disorders. Previously, we reported that chalcones are important for preventing biological disorders, such as diabetes. In this study, we demonstrate that the synthetic halogen-containing chalcone derivatives 2-bromo-4'-methoxychalcone (compound 5) and 2-iodo-4'-methoxychalcone (compound 6) can promote glucose consumption and inhibit cellular lipid accumulation via 5'-adenosine-monophosphate-activated protein kinase (AMPK) activation and acetyl-CoA carboxylase 1 (ACC) phosphorylation in 3T3-L1 adipocytes and C2C12 skeletal myotubes. In addition, the two compounds significantly prevented body weight gain and impaired glucose tolerance, hyperinsulinemia, and insulin resistance, which collectively help to delay the progression of hyperglycemia in high-fat-diet-induced obese C57BL/6 mice. These findings indicate that 2-bromo-4'-methoxychalcone and 2-iodo-4'-methoxychalcone could act as AMPK activators, and may serve as lead compounds for a new class of medicines that target obesity and diabetes.

DOI: 10.3390/ijms19092763
PubMed: 30223438
PubMed Central: PMC6163633

Affiliations:

Taïwan

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000675
to stream Main, to step Curation: 000675

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">2-Bromo-4'-methoxychalcone and 2-Iodo-4'-methoxychalcone Prevent Progression of Hyperglycemia and Obesity via 5'-Adenosine-Monophosphate-Activated Protein Kinase in Diet-Induced Obese Mice.</title>
<author><name sortKey="Hsieh, Chi Ting" sort="Hsieh, Chi Ting" uniqKey="Hsieh C" first="Chi-Ting" last="Hsieh">Chi-Ting Hsieh</name>
<affiliation wicri:level="1"><nlm:affiliation>Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan. u98831001@gmail.com.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807</wicri:regionArea>
<wicri:noRegion>Kaohsiung 807</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chang, Fang Rong" sort="Chang, Fang Rong" uniqKey="Chang F" first="Fang-Rong" last="Chang">Fang-Rong Chang</name>
<affiliation wicri:level="1"><nlm:affiliation>Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan. aaronfrc@kmu.edu.tw.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807</wicri:regionArea>
<wicri:noRegion>Kaohsiung 807</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Department of Marine Biotechnology and Resources, College of Marine Sciences, National Sun Yat-sen University, Kaohsiung 804, Taiwan. aaronfrc@kmu.edu.tw.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Marine Biotechnology and Resources, College of Marine Sciences, National Sun Yat-sen University, Kaohsiung 804</wicri:regionArea>
<wicri:noRegion>Kaohsiung 804</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tsai, Yi Hong" sort="Tsai, Yi Hong" uniqKey="Tsai Y" first="Yi-Hong" last="Tsai">Yi-Hong Tsai</name>
<affiliation wicri:level="1"><nlm:affiliation>Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan. lyph0719@hotmail.com.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807</wicri:regionArea>
<wicri:noRegion>Kaohsiung 807</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wu, Yang Chang" sort="Wu, Yang Chang" uniqKey="Wu Y" first="Yang-Chang" last="Wu">Yang-Chang Wu</name>
<affiliation wicri:level="1"><nlm:affiliation>Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan. yachwu@kmu.edu.tw.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807</wicri:regionArea>
<wicri:noRegion>Kaohsiung 807</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hsieh, Tusty Jiuan" sort="Hsieh, Tusty Jiuan" uniqKey="Hsieh T" first="Tusty-Jiuan" last="Hsieh">Tusty-Jiuan Hsieh</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Marine Biotechnology and Resources, College of Marine Sciences, National Sun Yat-sen University, Kaohsiung 804, Taiwan. hsiehjun@kmu.edu.tw.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Marine Biotechnology and Resources, College of Marine Sciences, National Sun Yat-sen University, Kaohsiung 804</wicri:regionArea>
<wicri:noRegion>Kaohsiung 804</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan. hsiehjun@kmu.edu.tw.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807</wicri:regionArea>
<wicri:noRegion>Kaohsiung 807</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan. hsiehjun@kmu.edu.tw.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung 807</wicri:regionArea>
<wicri:noRegion>Kaohsiung 807</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Lipid Science and Aging Research Center, Kaohsiung Medical University, Kaohsiung 807, Taiwan. hsiehjun@kmu.edu.tw.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Lipid Science and Aging Research Center, Kaohsiung Medical University, Kaohsiung 807</wicri:regionArea>
<wicri:noRegion>Kaohsiung 807</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2018">2018</date>
<idno type="RBID">pubmed:30223438</idno>
<idno type="pmid">30223438</idno>
<idno type="doi">10.3390/ijms19092763</idno>
<idno type="pmc">PMC6163633</idno>
<idno type="wicri:Area/Main/Corpus">000675</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000675</idno>
<idno type="wicri:Area/Main/Curation">000675</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000675</idno>
<idno type="wicri:Area/Main/Exploration">000675</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">2-Bromo-4'-methoxychalcone and 2-Iodo-4'-methoxychalcone Prevent Progression of Hyperglycemia and Obesity via 5'-Adenosine-Monophosphate-Activated Protein Kinase in Diet-Induced Obese Mice.</title>
<author><name sortKey="Hsieh, Chi Ting" sort="Hsieh, Chi Ting" uniqKey="Hsieh C" first="Chi-Ting" last="Hsieh">Chi-Ting Hsieh</name>
<affiliation wicri:level="1"><nlm:affiliation>Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan. u98831001@gmail.com.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807</wicri:regionArea>
<wicri:noRegion>Kaohsiung 807</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chang, Fang Rong" sort="Chang, Fang Rong" uniqKey="Chang F" first="Fang-Rong" last="Chang">Fang-Rong Chang</name>
<affiliation wicri:level="1"><nlm:affiliation>Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan. aaronfrc@kmu.edu.tw.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807</wicri:regionArea>
<wicri:noRegion>Kaohsiung 807</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Department of Marine Biotechnology and Resources, College of Marine Sciences, National Sun Yat-sen University, Kaohsiung 804, Taiwan. aaronfrc@kmu.edu.tw.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Marine Biotechnology and Resources, College of Marine Sciences, National Sun Yat-sen University, Kaohsiung 804</wicri:regionArea>
<wicri:noRegion>Kaohsiung 804</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tsai, Yi Hong" sort="Tsai, Yi Hong" uniqKey="Tsai Y" first="Yi-Hong" last="Tsai">Yi-Hong Tsai</name>
<affiliation wicri:level="1"><nlm:affiliation>Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan. lyph0719@hotmail.com.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807</wicri:regionArea>
<wicri:noRegion>Kaohsiung 807</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wu, Yang Chang" sort="Wu, Yang Chang" uniqKey="Wu Y" first="Yang-Chang" last="Wu">Yang-Chang Wu</name>
<affiliation wicri:level="1"><nlm:affiliation>Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan. yachwu@kmu.edu.tw.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807</wicri:regionArea>
<wicri:noRegion>Kaohsiung 807</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hsieh, Tusty Jiuan" sort="Hsieh, Tusty Jiuan" uniqKey="Hsieh T" first="Tusty-Jiuan" last="Hsieh">Tusty-Jiuan Hsieh</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Marine Biotechnology and Resources, College of Marine Sciences, National Sun Yat-sen University, Kaohsiung 804, Taiwan. hsiehjun@kmu.edu.tw.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Marine Biotechnology and Resources, College of Marine Sciences, National Sun Yat-sen University, Kaohsiung 804</wicri:regionArea>
<wicri:noRegion>Kaohsiung 804</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan. hsiehjun@kmu.edu.tw.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807</wicri:regionArea>
<wicri:noRegion>Kaohsiung 807</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan. hsiehjun@kmu.edu.tw.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung 807</wicri:regionArea>
<wicri:noRegion>Kaohsiung 807</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Lipid Science and Aging Research Center, Kaohsiung Medical University, Kaohsiung 807, Taiwan. hsiehjun@kmu.edu.tw.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Lipid Science and Aging Research Center, Kaohsiung Medical University, Kaohsiung 807</wicri:regionArea>
<wicri:noRegion>Kaohsiung 807</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">International journal of molecular sciences</title>
<idno type="eISSN">1422-0067</idno>
<imprint><date when="2018" type="published">2018</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>AMP-Activated Protein Kinases (metabolism)</term>
<term>Adipocytes (drug effects)</term>
<term>Adipocytes (metabolism)</term>
<term>Animals (MeSH)</term>
<term>CCAAT-Enhancer-Binding Proteins (metabolism)</term>
<term>Cell Line (MeSH)</term>
<term>Chalcones (chemistry)</term>
<term>Chalcones (pharmacology)</term>
<term>Diet, High-Fat (adverse effects)</term>
<term>Disease Models, Animal (MeSH)</term>
<term>Disease Progression (MeSH)</term>
<term>Enzyme Activation (MeSH)</term>
<term>Glucose (metabolism)</term>
<term>Hyperglycemia (blood)</term>
<term>Hyperglycemia (metabolism)</term>
<term>Hyperglycemia (prevention & control)</term>
<term>Hypoglycemic Agents (chemistry)</term>
<term>Hypoglycemic Agents (pharmacology)</term>
<term>Lipid Metabolism (drug effects)</term>
<term>Mice (MeSH)</term>
<term>Muscle Fibers, Skeletal (drug effects)</term>
<term>Muscle Fibers, Skeletal (metabolism)</term>
<term>Obesity (blood)</term>
<term>Obesity (etiology)</term>
<term>Obesity (metabolism)</term>
<term>Obesity (prevention & control)</term>
<term>PPAR gamma (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>AMP-Activated Protein Kinases (métabolisme)</term>
<term>Activation enzymatique (MeSH)</term>
<term>Adipocytes (effets des médicaments et des substances chimiques)</term>
<term>Adipocytes (métabolisme)</term>
<term>Alimentation riche en graisse (effets indésirables)</term>
<term>Animaux (MeSH)</term>
<term>Chalcones (composition chimique)</term>
<term>Chalcones (pharmacologie)</term>
<term>Fibres musculaires squelettiques (effets des médicaments et des substances chimiques)</term>
<term>Fibres musculaires squelettiques (métabolisme)</term>
<term>Glucose (métabolisme)</term>
<term>Hyperglycémie (métabolisme)</term>
<term>Hyperglycémie (prévention et contrôle)</term>
<term>Hyperglycémie (sang)</term>
<term>Hypoglycémiants (composition chimique)</term>
<term>Hypoglycémiants (pharmacologie)</term>
<term>Lignée cellulaire (MeSH)</term>
<term>Modèles animaux de maladie humaine (MeSH)</term>
<term>Métabolisme lipidique (effets des médicaments et des substances chimiques)</term>
<term>Obésité (métabolisme)</term>
<term>Obésité (prévention et contrôle)</term>
<term>Obésité (sang)</term>
<term>Obésité (étiologie)</term>
<term>Protéines liant les séquences stimulatrices de type CCAAT (métabolisme)</term>
<term>Récepteur PPAR gamma (métabolisme)</term>
<term>Souris (MeSH)</term>
<term>Évolution de la maladie (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Chalcones</term>
<term>Hypoglycemic Agents</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>AMP-Activated Protein Kinases</term>
<term>CCAAT-Enhancer-Binding Proteins</term>
<term>Glucose</term>
<term>PPAR gamma</term>
</keywords>
<keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Diet, High-Fat</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Hyperglycemia</term>
<term>Obesity</term>
</keywords>
<keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Chalcones</term>
<term>Hypoglycémiants</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Adipocytes</term>
<term>Lipid Metabolism</term>
<term>Muscle Fibers, Skeletal</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Adipocytes</term>
<term>Fibres musculaires squelettiques</term>
<term>Métabolisme lipidique</term>
</keywords>
<keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Alimentation riche en graisse</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Obesity</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Adipocytes</term>
<term>Hyperglycemia</term>
<term>Muscle Fibers, Skeletal</term>
<term>Obesity</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>AMP-Activated Protein Kinases</term>
<term>Adipocytes</term>
<term>Fibres musculaires squelettiques</term>
<term>Glucose</term>
<term>Hyperglycémie</term>
<term>Obésité</term>
<term>Protéines liant les séquences stimulatrices de type CCAAT</term>
<term>Récepteur PPAR gamma</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Chalcones</term>
<term>Hypoglycémiants</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Chalcones</term>
<term>Hypoglycemic Agents</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Hyperglycemia</term>
<term>Obesity</term>
</keywords>
<keywords scheme="MESH" qualifier="prévention et contrôle" xml:lang="fr"><term>Hyperglycémie</term>
<term>Obésité</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Hyperglycémie</term>
<term>Obésité</term>
</keywords>
<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Obésité</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cell Line</term>
<term>Disease Models, Animal</term>
<term>Disease Progression</term>
<term>Enzyme Activation</term>
<term>Mice</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Activation enzymatique</term>
<term>Animaux</term>
<term>Lignée cellulaire</term>
<term>Modèles animaux de maladie humaine</term>
<term>Souris</term>
<term>Évolution de la maladie</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Obesity and diabetes are global health-threatening issues. Interestingly, the mechanism of these pathologies is quite different among individuals. The discovery and development of new categories of medicines from diverse sources are urgently needed for preventing and treating diabetes and other metabolic disorders. Previously, we reported that chalcones are important for preventing biological disorders, such as diabetes. In this study, we demonstrate that the synthetic halogen-containing chalcone derivatives 2-bromo-4'-methoxychalcone (compound <b>5</b>
) and 2-iodo-4'-methoxychalcone (compound <b>6</b>
) can promote glucose consumption and inhibit cellular lipid accumulation via 5'-adenosine-monophosphate-activated protein kinase (AMPK) activation and acetyl-CoA carboxylase 1 (ACC) phosphorylation in 3T3-L1 adipocytes and C2C12 skeletal myotubes. In addition, the two compounds significantly prevented body weight gain and impaired glucose tolerance, hyperinsulinemia, and insulin resistance, which collectively help to delay the progression of hyperglycemia in high-fat-diet-induced obese C57BL/6 mice. These findings indicate that 2-bromo-4'-methoxychalcone and 2-iodo-4'-methoxychalcone could act as AMPK activators, and may serve as lead compounds for a new class of medicines that target obesity and diabetes.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30223438</PMID>
<DateCompleted><Year>2018</Year>
<Month>12</Month>
<Day>24</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>12</Month>
<Day>24</Day>
</DateRevised>
<Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1422-0067</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>19</Volume>
<Issue>9</Issue>
<PubDate><Year>2018</Year>
<Month>Sep</Month>
<Day>14</Day>
</PubDate>
</JournalIssue>
<Title>International journal of molecular sciences</Title>
<ISOAbbreviation>Int J Mol Sci</ISOAbbreviation>
</Journal>
<ArticleTitle>2-Bromo-4'-methoxychalcone and 2-Iodo-4'-methoxychalcone Prevent Progression of Hyperglycemia and Obesity via 5'-Adenosine-Monophosphate-Activated Protein Kinase in Diet-Induced Obese Mice.</ArticleTitle>
<ELocationID EIdType="pii" ValidYN="Y">E2763</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.3390/ijms19092763</ELocationID>
<Abstract><AbstractText>Obesity and diabetes are global health-threatening issues. Interestingly, the mechanism of these pathologies is quite different among individuals. The discovery and development of new categories of medicines from diverse sources are urgently needed for preventing and treating diabetes and other metabolic disorders. Previously, we reported that chalcones are important for preventing biological disorders, such as diabetes. In this study, we demonstrate that the synthetic halogen-containing chalcone derivatives 2-bromo-4'-methoxychalcone (compound <b>5</b>
) and 2-iodo-4'-methoxychalcone (compound <b>6</b>
) can promote glucose consumption and inhibit cellular lipid accumulation via 5'-adenosine-monophosphate-activated protein kinase (AMPK) activation and acetyl-CoA carboxylase 1 (ACC) phosphorylation in 3T3-L1 adipocytes and C2C12 skeletal myotubes. In addition, the two compounds significantly prevented body weight gain and impaired glucose tolerance, hyperinsulinemia, and insulin resistance, which collectively help to delay the progression of hyperglycemia in high-fat-diet-induced obese C57BL/6 mice. These findings indicate that 2-bromo-4'-methoxychalcone and 2-iodo-4'-methoxychalcone could act as AMPK activators, and may serve as lead compounds for a new class of medicines that target obesity and diabetes.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hsieh</LastName>
<ForeName>Chi-Ting</ForeName>
<Initials>CT</Initials>
<AffiliationInfo><Affiliation>Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan. u98831001@gmail.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chang</LastName>
<ForeName>Fang-Rong</ForeName>
<Initials>FR</Initials>
<Identifier Source="ORCID">0000-0003-2549-4193</Identifier>
<AffiliationInfo><Affiliation>Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan. aaronfrc@kmu.edu.tw.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Marine Biotechnology and Resources, College of Marine Sciences, National Sun Yat-sen University, Kaohsiung 804, Taiwan. aaronfrc@kmu.edu.tw.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tsai</LastName>
<ForeName>Yi-Hong</ForeName>
<Initials>YH</Initials>
<AffiliationInfo><Affiliation>Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan. lyph0719@hotmail.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wu</LastName>
<ForeName>Yang-Chang</ForeName>
<Initials>YC</Initials>
<AffiliationInfo><Affiliation>Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan. yachwu@kmu.edu.tw.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hsieh</LastName>
<ForeName>Tusty-Jiuan</ForeName>
<Initials>TJ</Initials>
<Identifier Source="ORCID">0000-0001-5387-6522</Identifier>
<AffiliationInfo><Affiliation>Department of Marine Biotechnology and Resources, College of Marine Sciences, National Sun Yat-sen University, Kaohsiung 804, Taiwan. hsiehjun@kmu.edu.tw.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan. hsiehjun@kmu.edu.tw.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan. hsiehjun@kmu.edu.tw.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Lipid Science and Aging Research Center, Kaohsiung Medical University, Kaohsiung 807, Taiwan. hsiehjun@kmu.edu.tw.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>NSC 98-2323-B-037-004, NSC 99-2323-B-037-002, NSC 102-2911-I-037-501</GrantID>
<Agency>Ministry of Science and Technology, Taiwan, R.O.C.</Agency>
<Country></Country>
</Grant>
<Grant><GrantID>KMU-TP103D07, KMU-TP103D20, KMU-TP103A21</GrantID>
<Agency>Kaohsiung Medical University</Agency>
<Country></Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2018</Year>
<Month>09</Month>
<Day>14</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>Switzerland</Country>
<MedlineTA>Int J Mol Sci</MedlineTA>
<NlmUniqueID>101092791</NlmUniqueID>
<ISSNLinking>1422-0067</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D022762">CCAAT-Enhancer-Binding Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C530718">CEBPA protein, mouse</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D047188">Chalcones</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D007004">Hypoglycemic Agents</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D047495">PPAR gamma</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>959-23-9</RegistryNumber>
<NameOfSubstance UI="C097470">4'-methoxychalcone</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.11.31</RegistryNumber>
<NameOfSubstance UI="D055372">AMP-Activated Protein Kinases</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>IY9XDZ35W2</RegistryNumber>
<NameOfSubstance UI="D005947">Glucose</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D055372" MajorTopicYN="N">AMP-Activated Protein Kinases</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017667" MajorTopicYN="N">Adipocytes</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D022762" MajorTopicYN="N">CCAAT-Enhancer-Binding Proteins</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002460" MajorTopicYN="N">Cell Line</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D047188" MajorTopicYN="N">Chalcones</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D059305" MajorTopicYN="N">Diet, High-Fat</DescriptorName>
<QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004195" MajorTopicYN="N">Disease Models, Animal</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018450" MajorTopicYN="N">Disease Progression</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004789" MajorTopicYN="N">Enzyme Activation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005947" MajorTopicYN="N">Glucose</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006943" MajorTopicYN="N">Hyperglycemia</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
<QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007004" MajorTopicYN="N">Hypoglycemic Agents</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D050356" MajorTopicYN="N">Lipid Metabolism</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018485" MajorTopicYN="N">Muscle Fibers, Skeletal</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009765" MajorTopicYN="N">Obesity</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
<QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
<QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D047495" MajorTopicYN="N">PPAR gamma</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">adipocyte</Keyword>
<Keyword MajorTopicYN="N">chalcone</Keyword>
<Keyword MajorTopicYN="N">flavonoid</Keyword>
<Keyword MajorTopicYN="N">halogen</Keyword>
<Keyword MajorTopicYN="N">skeletal muscle</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year>
<Month>08</Month>
<Day>27</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2018</Year>
<Month>09</Month>
<Day>12</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2018</Year>
<Month>09</Month>
<Day>13</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2018</Year>
<Month>9</Month>
<Day>19</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2018</Year>
<Month>9</Month>
<Day>19</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2018</Year>
<Month>12</Month>
<Day>26</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>epublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">30223438</ArticleId>
<ArticleId IdType="pii">ijms19092763</ArticleId>
<ArticleId IdType="doi">10.3390/ijms19092763</ArticleId>
<ArticleId IdType="pmc">PMC6163633</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>Mol Nutr Food Res. 2011 Mar;55(3):467-75</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20938990</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Nutr Biochem. 2012 Jul;23(7):759-67</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21840191</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Diabetes Metab J. 2013 Feb;37(1):1-21</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23441028</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Physiol Endocrinol Metab. 2007 Dec;293(6):E1503-10</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17848630</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Bioorg Med Chem Lett. 2011 Jun 1;21(11):3475-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21515043</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eur J Med Chem. 2011 Aug;46(8):3469-73</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21624712</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Bioorg Med Chem Lett. 2012 Jun 15;22(12):3912-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22608392</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Med Chem. 2003 Aug;10(15):1353-74</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12871134</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Wei Sheng Yan Jiu. 2013 Jan;42(1):107-9, 113</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23596719</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Phytomedicine. 2012 Dec 15;20(1):32-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23083813</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Diabetes Care. 2012 Jun;35(6):1364-79</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22517736</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Bioorg Med Chem. 2004 Mar 1;12(5):883-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14980600</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Agric Food Chem. 2007 Jul 25;55(15):6013-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17583349</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Appl Physiol (1985). 1997 Jan;82(1):219-25</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9029219</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Acta Biochim Pol. 2010;57(4):553-60</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21060897</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biosci Biotechnol Biochem. 2012;76(5):961-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22738967</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Methods Mol Biol. 2012;933:219-28</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22893410</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Prod Rep. 2010 Jun;27(6):809-38</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20358127</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Asian Nat Prod Res. 2009 Dec;11(12):1045-55</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20183275</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int Immunopharmacol. 2011 Mar;11(3):295-309</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21184860</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Phytochemistry. 2006 Jul;67(14):1539-46</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16806328</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Pharm Pharmacol. 2001 May;53(5):653-68</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11370705</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Pharm Pharmacol. 2008 Sep;60(9):1227-36</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18718128</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Methods Mol Biol. 2012;933:161-74</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22893406</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Food Chem Toxicol. 2012 Mar;50(3-4):779-89</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22222928</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Bioorg Chem. 2010 Aug;38(4):139-43</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20457464</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Chem Biol. 2012 Oct 26;19(10):1222-36</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23102217</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Diabetes. 2003 Jul;52(7):1635-40</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12829626</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Br J Pharmacol. 2014 Feb;171(3):595-617</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24490856</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Diabetes. 2007 Nov;56(11):2655-67</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17827399</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Mol Sci. 2017 Jan 29;18(2):</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28146060</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Med Sci. 1949 Mar;217(3):277-82</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18123875</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Phytomedicine. 2009 May;16(5):437-43</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19188054</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cell Endocrinol. 2013 Feb 25;366(2):204-14</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22796442</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>ACS Chem Biol. 2013 Oct 18;8(10):2301-11</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23962138</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Rev Diabet Stud. 2009 Spring;6(1):13-36</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19557293</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Chem Pharm Bull (Tokyo). 2006 Mar;54(3):368-71</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16508194</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Bioorg Med Chem Lett. 2011 Jan 1;21(1):228-33</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21129962</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Agric Food Chem. 2010 Mar 10;58(5):3205-12</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20146476</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Front Plant Sci. 2012 Sep 28;3:222</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23060891</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Cardiovasc Pharmacol. 2012 Apr;59(4):339-51</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22157260</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Metab. 2012 Jan 4;15(1):19-24</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22225873</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>IUBMB Life. 2013 Jul;65(7):572-83</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23671028</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochimie. 2009 Nov-Dec;91(11-12):1493-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19747522</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Bioorg Med Chem. 2000 May;8(5):1151-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10882025</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2007 Jan 18;356(3):213-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17229948</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Bioorg Med Chem Lett. 2010 Nov 15;20(22):6508-12</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20926293</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Physiol Endocrinol Metab. 2010 Apr;298(4):E751-60</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20103737</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genes Nutr. 2011 May;6(2):125-47</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21484163</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biol Pharm Bull. 2008 Aug;31(8):1626-30</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18670102</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Taïwan</li>
</country>
</list>
<tree><country name="Taïwan"><noRegion><name sortKey="Hsieh, Chi Ting" sort="Hsieh, Chi Ting" uniqKey="Hsieh C" first="Chi-Ting" last="Hsieh">Chi-Ting Hsieh</name>
</noRegion>
<name sortKey="Chang, Fang Rong" sort="Chang, Fang Rong" uniqKey="Chang F" first="Fang-Rong" last="Chang">Fang-Rong Chang</name>
<name sortKey="Chang, Fang Rong" sort="Chang, Fang Rong" uniqKey="Chang F" first="Fang-Rong" last="Chang">Fang-Rong Chang</name>
<name sortKey="Hsieh, Tusty Jiuan" sort="Hsieh, Tusty Jiuan" uniqKey="Hsieh T" first="Tusty-Jiuan" last="Hsieh">Tusty-Jiuan Hsieh</name>
<name sortKey="Hsieh, Tusty Jiuan" sort="Hsieh, Tusty Jiuan" uniqKey="Hsieh T" first="Tusty-Jiuan" last="Hsieh">Tusty-Jiuan Hsieh</name>
<name sortKey="Hsieh, Tusty Jiuan" sort="Hsieh, Tusty Jiuan" uniqKey="Hsieh T" first="Tusty-Jiuan" last="Hsieh">Tusty-Jiuan Hsieh</name>
<name sortKey="Hsieh, Tusty Jiuan" sort="Hsieh, Tusty Jiuan" uniqKey="Hsieh T" first="Tusty-Jiuan" last="Hsieh">Tusty-Jiuan Hsieh</name>
<name sortKey="Tsai, Yi Hong" sort="Tsai, Yi Hong" uniqKey="Tsai Y" first="Yi-Hong" last="Tsai">Yi-Hong Tsai</name>
<name sortKey="Wu, Yang Chang" sort="Wu, Yang Chang" uniqKey="Wu Y" first="Yang-Chang" last="Wu">Yang-Chang Wu</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Bois/explor/BiopestPeptidV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A69 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000A69 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Bois
   |area=    BiopestPeptidV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:30223438
   |texte=   2-Bromo-4'-methoxychalcone and 2-Iodo-4'-methoxychalcone Prevent Progression of Hyperglycemia and Obesity via 5'-Adenosine-Monophosphate-Activated Protein Kinase in Diet-Induced Obese Mice.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:30223438" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a BiopestPeptidV1

This area was generated with Dilib version V0.6.38.
Data generation: Thu Nov 19 19:22:35 2020. Site generation: Thu Nov 19 19:33:26 2020

	Serveur d'exploration sur les peptides biopesticides
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur les peptides biopesticides

2-Bromo-4'-methoxychalcone and 2-Iodo-4'-methoxychalcone Prevent Progression of Hyperglycemia and Obesity via 5'-Adenosine-Monophosphate-Activated Protein Kinase in Diet-Induced Obese Mice.

2-Bromo-4'-methoxychalcone and 2-Iodo-4'-methoxychalcone Prevent Progression of Hyperglycemia and Obesity via 5'-Adenosine-Monophosphate-Activated Protein Kinase in Diet-Induced Obese Mice.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki